Nuclear stiffening along with RhoGEF activity regulate RhoA/MyosinII-dependent contractility and cell migration phenotype in confinement
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This presentation highlighted signaling pathways that are activated in invasive breast cancer cells when nuclei are confined during migration in synthetic microfluidic devices – a finding that can be extrapolated to contricted passageways in the body such as pre-existing perineural spaces and bone cavities or channels created by macrophages and cancer-associated fibroblasts through ECM remodeling.
Recommended citation: Wisniewski E, Mistriotis P, Bera K, Zhang J, Nikolic M, Tuntithavornwat S, Law R, Zhao R, Habib D, Kalab P, Scarcelli G, Konstantopoulos K. Nuclear stiffening along with RhoGEF activity regulate RhoA/MyosinII-dependent contractility and cell migration phenotype in confinement. Poster presented at: Biomedical Engineering Society Annual Meeting; October 16, 2020; Virtual.
