Less is more: Risk factors and survival outcomes of overtreatment for early-stage colorectal cancer
Journal of Surgical Oncology, 2025
This study examined overtreatment in early-stage (cT1-2N0M0) colorectal cancer (CRC) patients who underwent definitive resection without pathologic upstaging. Using National Cancer Database (NCDB) data from 2010–2020, we identified risk factors for overtreatment and analyzed its impact on overall survival (OS). Younger age, Black race, and pT2 tumors were linked to overtreatment in colon cancer, while pT2 stage, poor differentiation, and high-risk histology were associated with rectal cancer overtreatment. Overtreatment correlated with worse OS in colon cancer but not in rectal cancer.
Recommended citation: Habib DRS, Shou M, Rogers JL, Sun K, Wang C, Khan A. Less is more: Risk factors and survival outcomes of overtreatment for early-stage colorectal cancer. J Surg Oncol. 2025. doi:10.1002/jso.70028